General Information

  • ID:  hor002510
  • Uniprot ID:  NA
  • Protein name:  neuropeptide NAP
  • Gene name:  NA
  • Organism:  NA
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  NAPVSIPQ
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Caused permeabilization of HL60 cells at neutral pH
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: 0.5 mM
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002510_AF2.pdbhor002510_ESM.pdb

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Physical Information

Mass: 94997 Formula: C36H60N10O12
Absent amino acids: CDEFGHKLMRTWY Common amino acids: P
pI: 6.11 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -6.25 Boman Index: -481
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 97.5
Instability Index: 7737.5 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  21757007
  • Title:  Membrane Permeabilization by Alpha-Helical Peptides: A Flow Cytometry Study